Studio finanziato dalla Brain Research Foundation Verona.

Articolo pubblicato online il 15 ottobre 2020:

© 2020 The Author(s). Published by Frontiers in Immunology.


Alberto Beretta, Martin Cranage, Donato Zipeto.


The serological responses to both SARS-CoV-1 and SARS-CoV-2 virus have some unique characteristics that suggest cross-reactive priming by other human coronaviruses (hCoVs). The early kinetics and magnitude of these responses are, in some cases, associated with worse clinical outcomes in SARS and COVID-19. Cross-reactive hCoV antibody responses have been detected in both SARS and COVID-19 patients. There is also evidence that pre-existing T cell immunity to common cold coronaviruses can prime the response to SARS-CoV-2. Studies in non-human primates show that SARS-CoV-1 S-protein vaccine-induced antibodies are associated with acute lung injury in macaques challenged with SARS-CoV-1. Here we discuss the potential of cross-reactive immunity to drive the immunopathogenesis of COVID-19 and its implications for current efforts to develop immune-based therapies and vaccines.

Responsabile: Alberto Beretta – Solongevity Research, Milano –

Articolo open access con licenza CC BY Creative Commons.

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